Comprehensive Traditional Knowledge Digital Library (CTKDL) is an initiative to create a digitized database on traditional knowledge related to medicinal plants, foods, yoga practices and traditional musical instruments. It has been successful in getting due credit to India and protect this knowledge within the patent system in the interest of the knowledge holders. Ten CSIR laboratories participated to collect, collate and digitize information on 2609 medicinal plants used in Ayurvedic system of medicine. The digitized knowledge base generated has proved to be an effective tool in preventing misappropriation of Indian traditional knowledge by making it available to patent examiners. IITR is providing toxicological information and antidote potential of medicinal plants and their constituents used in Ayurveda, as a step towards value addition. Information on all 2609 medicinal plants was collected, collated, validated and uploaded on the nodal database at TKDL. 3D molecular structures of 1800 pharmacologically active constituents including toxicants, has also been uploaded in the database. This shall help in finding probable drug targets using computational biology tools, which is valuable for researchers involved in new drug development. The structures can also help in prediction of toxicity in silico.